Our scientific interest is to gain insight in molecular mechanisms in biological systems from the points of view of structural, molecular and computational biology. The key to this is the 3-dimensional structure of a macromolecule resolved in atomic details.
Our major research areas have roots in endosomal protein degradation: we study molecular players of infectious diseases, antigen response and iodine cycle.
We use biochemistry, molecular and cell biology, macromolecular crystallography, and computational biology and collaborate with groups that use electron microscopy, small angle X-ray scattering, organic synthesis, mass spec analysis and proteomics, and cell and computational biology.
We actively support and run infrastructure for protein production and structure determination at JSI and CIPKeBiP and are open to collaborations.