Statement:

Our scientific interest is to gain insight in molecular mechanisms in biological systems from the points of view of structural, molecular and computational biology. The key to this is the 3-dimensional structure of a macromolecule resolved in atomic details.

Our major research areas have roots in endosomal protein degradation: we study molecular players of infectious diseases, antigen response and iodine cycle.

• Mechanisms of endosomal antigen presentation. We study molecules involved in endosomal immune response system with focus on proteases and other enzymes, their inhibitors and MHC class II molecules.
• Proteins at the surface of pathogen bacteria (S. aureus, C. dificcile), We study molecules that build and rebuild peptidoglycan and protein (S-layer) surface including biofilm and those involved in their making.
• Iodine metabolism. We study T3 T4 hormone synthesis (thyroglobulin) and enzymes involved in hormone regulation.
• We develop computational tools for structural biology.

We use biochemistry, molecular and cell biology, macromolecular crystallography, and computational biology and collaborate with groups that use electron microscopy, small angle X-ray scattering, organic synthesis, mass spec analysis and proteomics, and cell and computational biology.

We actively support and run infrastructure for protein production and structure determination at JSI and CIPKeBiP and are open to collaborations.