Physiological processes can be reproduced at in vitro level once we can bring together all molecular players and understand their interactions. Our scientific interest is to gain insight in molecular mechanisms in biological systems from the points of view of structural, molecular and computational biology. To understand intra- and intermolecular interactions it is essential to have insight in the 3-dimensional structure of a macromolecule resolved to atomic details.
Our major research areas are:
We use biochemistry, molecular and cell biology, macromolecular crystallography, and computational biology and collaborate with groups that use electron microscopy, small angle X-ray scattering, organic synthesis, mass spec analysis and proteomics, and cell and computational biology.
We actively support and run infrastructure for protein production and structure determination at JSI and CIPKeBiP and are open to collaborations.